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The models reliably recapitulate the histopathological properties of their parental primary tumors.
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These mouse models faithfully recapitulate the pathology and disease course seen in the human patients.
We also show that this system can reliably recapitulate the standard caudal vein injection method with a throughput level of 2,000 embryos per hour.
Taken together, these results provided evidence that the Ppt1-KI mice reliably recapitulate the characteristic pathology reported in INCL patients and in Ppt1 −/− mice.
Our findings show that Ppt1-KI mice reliably recapitulate INCL phenotype providing a platform for testing the efficacy of existing and novel nonsense suppressors in vivo.
The key consideration in evaluating the utility of lineage-converted cells is how similar they are to their primary counterparts and whether they reliably recapitulate disease phenotypes.
Conversely, an animal model of blast neurotrauma that reliably recapitulates neuropathology and neurobehavioral deficits observed in blast-exposed humans may prove useful in providing clinically relevant information regarding blast TBI, but less informative with respect to accurate determination of scaling factors and biomechanical constants for finite element analysis.
This indicates that the AC/AE model faithfully recapitulates early heart development (Fig. S3).
The focus of our work is a series of genetically engineered mouse models that faithfully recapitulate human disease.
However, these models do not faithfully recapitulate human tumors.
Next, we evaluated whether the PHH and HepaRG spheroid models can recapitulate the mechanisms associated with DIC.
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