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Studies on these models provided further evidence for a causative connection between OPA1 mutations and ascending RGC death, making ADOA a true neurodegenerative disease.
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New evidence of increased incidence of ANFH in specific animal models provides further evidence of genetic susceptibility [ 11].
Their models provide further insights into the processes that may play a prominent role for the fate of asexual clones.
Totally, the mapped expression data cover 78.82% and 87.16% of annotated japonica and indica gene models, providing further support for 98.12% and 90.29% of the japonica and indica cDNAs.
In addition, leukemia-initiating cells (LICs), which are responsible for relapse of leukemia, could be cleared by ATRA/ATO based treatment in murine models, providing further rationale of combined use of the two agents (Au et al., 2001, Ito et al., 2008, Nasr and de The, 2010, Nasr et al., 2008, Zhou et al., 2010).
Our finding that several proteins whose expression profiles are known to reflect the vulnerability status of axons and synapses have modified expression levels in the brains of two NCL mouse models provides further evidence in support of synaptic and axonal vulnerability in these disorders.
In progressive metastatic breast cancer patients with hormone receptor-positive tumors and large numbers of CTCs, only CTC subsets that expressed the surface proteins EPCAM, CD44, CD47 and MET were capable of forming metastases when injected into the bone marrow of xenograft models, providing further evidence that only some CTC populations initiate metastases [ 5].
However, when considered as a proportion of the overall variance, these are very small (always less than 2%, see Table 1), and so these models provide further evidence that any variation in DUP at the neighbourhood level is unlikely to be meaningful from a clinical or public health perspective.
A recent study using the in vitro ESCs differentiation model provided further evidence that Mesp1 plays a key role in specifying cardiac development.
Additional docking experiments with selective hCYP27B1 or hCYP24A1 inhibitors using both the hCYP27B1 model and a triple mutant hCYP24A1 model provided further support for the importance of H-bonding interactions with the three identified active site amino acids.
Finally, adding plasma CT-proET-1 to plasma NT-proBNP in this model provided further prognostic information.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com