The transport of macromolecules through the endothelium has been modeled previously considering two main pathways: transport through vesicular transcytosis (regulated by receptors on the endothelial cells) 10 and transport through leaky and normal junctions, most of which are located at the sites of dying or replicating cells.
Comparative studies with a finite element solution free of any kinematics assumptions have been conducted to address the applicability and the efficiency of previously considered models and theories.
We also show that another group of model structures (IP group), previously considered less plausible, and a number of previously not considered model structures, are still equally capable of reproducing the observations and expectations and should still be consideredas relevant.
Based on a three-dimensional (3D) statistical resistor network model [11], we have previously considered the change of internal CNT conductive network and tunneling effect in exploring the piezoresistivity behavior of the above CNT/polymer nanocomposite strain sensors [12].
Although PBPK modeling in risk assessment is intended to provide more accurate estimates of dose relative to default procedures, it should be recognized that in some cases, rigorous analysis of PBPK models may reveal uncertainties not previously considered or of greater magnitude than that which is assumed under default procedures.
We consider the Poisson, negative binomial, and sCMP(m) models where m=1,2,3,4 to describe the data distribution; Bailey (1990) previously considered a binomial model to describe the data.
The remarkably simple yet realistic Hogner model of farfield ship waves, previously considered to analyze the apparent wake angle associated with the highest waves that result from constructive interferences among the divergent waves created by a fast ship in deep water, is applied to the more general case of uniform finite water depth.
For instance this would make possible a previously considered elegant model (REF 7) of serial events of vesicular budding and fusion leading to delivery of the protein into the host cell without direct crossing of any membranes.
While the diminished cranial bone formation in these Fgfr-associated mouse models of craniosynostosis has not been previously considered as contributing to the development of craniosynostosis, it is interesting to note that craniosynostosis is also known to occur in other disorders of low bone mineralization.
