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Partial-least squares regression analysis was then used to construct models predictive of the resulting nepholometric turbidity to the acquired spectra.
LY2456302 is a centrally-penetrant, potent, kappa-selective antagonist with pharmacokinetic properties favorable for clinical development and activity in animal models predictive of efficacy in mood and addictive disorders.
In order to test this hypothesis we developed multivariate statistical models predictive of toxicity selecting from PCFs associated to molecular pathway activity.
The networks represented in Figure S5D and 4B represent the connection between genes including models predictive of tumour capsular penetrations and TGF.
Such levels of TP-10 are associated with robust increases in striatal levels of cAMP, cGMP, and CREB phosphorylation and robust efficacy in mouse behavioral models predictive of antipsychotic efficacy [33].
The first subset (92 features) was defined including descriptors represented in the models predictive of pathway activity whereas the second subset included all variables not selected in the predictive models and that were uncorrelated, an absolute pearson coefficient of less than 0.5, to PCFs from the first group (210 features).
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We published previously a model predictive of the need for exploration in small-bowel obstruction.
This study investigated the cardiovascular effects produced by these novel compounds in an experimental model predictive of systemic (cardio) vascular side effects.
Thus, nicotine, by itself, in the absence of behavioral or drug-exposure history, is a robust and highly effective reinforcer of drug-taking behavior in a non-human primate model predictive of human behavior.
Thus, not only is the model predictive of relative potency within these drug classes, it might also be useful in determining approximate dosing ranges for effective use in humans.
The FST is probably the most frequently used animal model predictive of antidepressant activity [ 45].
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