Previous models postulated symmetric binding energies for each state of the coarse-grained protein corresponding to the symmetry of the dimeric protein; this model relaxes this assumption by assigning different energies for the different steps in the unbinding process.
Specifically, a proportional hazards model is postulated for the effects of measured covariates and of one or more components of frailty that are unmeasured but assumed to have some common distribution and known covariance structure within each family.
In the first stage, a linear regression model is postulated for the true underlying pattern of change of cartilage volume over time for each individual (for instance, initial cartilage volume and rate of change), and these patterns are allowed to differ for each individual.
The most generally applicable models postulate fitness benefits for recombining organisms, either because of faster adaptation to changing conditions (e.g., the Red-Queen model) [9], [10], or because of more efficient purging of deleterious mutations (mutation-based models) [11], [12].
By linking Parkin-mediated polyubiquitination to the UPS, our results support, in a general sense, earlier models postulating a role for Parkin in cellular protein quality control (14).
Although they have evolved independently for more than 500 million years, most models postulate a monophyletic origin for vertebrate and invertebrate immune systems that predates the bifurcation in their evolution.
These models postulate specificity-conferring signatures for NRPS A-domains consisting of ten critical amino acid residues putatively involved in amino acid or aryl acid substrate specificity.
Phenomenological damage evolution models are then postulated for each constituent.
Pincus et al. [ 175, 176] cite distress/depressive mood as integral psychological factors in the transition from acute to chronic LBP and several psychosocial models have been postulated for the role of distress/depression in this transition [ 176, 177].
While some models argue that vectors are represented for navigational guidance, other models postulate that the future path is computed.
