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Generating and managing such candidate models poses a considerable challenge to the modeler.
The (global) optimization of energy systems, commonly characterized by high-fidelity and large-scale complex models, poses a formidable challenge partially due to the high noise and/or computational expense associated with the calculation of derivatives.
The computational cost associated with the use of high-fidelity computational fluid dynamics (CFD) models poses a serious impediment to the successful application of formal sensitivity analysis in engineering design.
The rapid development of ASD animal models poses a major challenge for systematic analysis of their content.
The rapid accumulation of putative candidate genes/loci for Autism Spectrum Disorders (ASD) and ASD-related animal models poses a major challenge for systematic analysis of their content.
This is achieved by means of linear optimization (maximization of a linear objective in constraint-based stoichiometric models poses a linear problem).
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In the case of teleost fish, extracting gene functional annotations from mammalian models poses an additional problem.
Nevertheless, these models pose a variety of problems with regards to security.
Flexible modes and high-dimensional models pose a major challenge to modern control design tools.
However, weight-drop models pose a number of substantial limitations.
However, for both interpretations, weakly deleterious mutation models pose a potential problem.
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