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Hidden Markov Models pose an opportunity for reducing the number of entries of a database and also enable to find distantly homologous sequences.
In terms of clinical utility, patient-specific structure function models pose an additional challenge.
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Nevertheless, these models pose a variety of problems with regards to security.
Flexible modes and high-dimensional models pose a major challenge to modern control design tools.
However, weight-drop models pose a number of substantial limitations.
However, for both interpretations, weakly deleterious mutation models pose a potential problem.
However, all these models pose a major conundrum: Ogt KO mice are early embryonic lethal whereas tet1/ tet2 double KO mice are viable and fertile (Dawlaty et al. 2013) and tet3 KO mice survive until after birth (Gu et al. 2011).
In the case of teleost fish, extracting gene functional annotations from mammalian models poses an additional problem.
Generating and managing such candidate models poses a considerable challenge to the modeler.
The (global) optimization of energy systems, commonly characterized by high-fidelity and large-scale complex models, poses a formidable challenge partially due to the high noise and/or computational expense associated with the calculation of derivatives.
The computational cost associated with the use of high-fidelity computational fluid dynamics (CFD) models poses a serious impediment to the successful application of formal sensitivity analysis in engineering design.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com