Sentence examples for models our pertussis from inspiring English sources

As with all models, our pertussis model is a simplified description of the underlying processes that lead to disease and of resource utilization.

We designed a discrete event simulation (DES) model to model pertussis transmission in the population [17] [19].

In conclusion, we designed a dynamic individual-based DES-model to model pertussis transmission in the population in order to estimate the cost-effectiveness of universal booster vaccination strategies.

44 If the specificity of our pertussis assay is low we may have overestimated maternal-specific pertussis antibody levels, and therefore may have underestimated the proportion of mothers and infants susceptible to pertussis.

By comparing wild type and PT-deficient B. pertussis strains in the mouse model, our group has recently shown that PT contributes significantly to bacterial growth in the respiratory tract by effects on host cells of the airways, including inhibitory effects on the protective role of resident airway macrophages [4], [5], [6].

To our knowledge we designed the first individual-based dynamic framework to model pertussis transmission in the population.

The aim of this study is to design an individual-based stochastic dynamic framework to model pertussis transmission in the population in order to predict the epidemiologic and economic consequences of the implementation of universal booster vaccination programs.

The cost-effectiveness analysis builds upon on a compartmental age-structured transmission model of pertussis in the US [25], which is an update of previous published transmission models of pertussis [26] [28].

Not taking into account age assortativity in epidemic models of pertussis has been shown to lead to misleading policy recommendations (Rohani et al. 2010).

Murine models of pertussis infection show that mice with a functional mutation in the TLR4 gene are more susceptible to infection (18, 19) and a candidate gene approach has indicated that variation in the human TLR-4 gene influences antibody response to pertussis vaccine (20– 20).

Although van Boven et al [23], [64] and Hethcote [65] [69] used a dynamic approach to model pertussis transmission, these models were not used for economic analyses.