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Current efforts in the FRDA field aim to generate better models that genetically reproduce the partial frataxin deficiency, mainly via the introduction of GAA-expansion-containing constructs in either mouse models or cells, or by the use of induced pluripotent stem cell (iPSC -derived cells.
To our knowledge, this localization has not been reported in animal models or cells yet, so it remains to be seen if it is a characteristic of these large polyploid cells and tissues, which primarily function as nutrient storing and metabolic organs in the fly larva.
Most studies of GRPs induction in tumors first have been conducted with animal models or cells in culture like breast cancer[ 4, 25] or colorectal[ 29, 30] cancer cell lines where correlated regulation of GRP78 and GRP94 gene expression was reported confirming our findings.
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The second approach tests small molecules on animal disease models or cell cultures (called phenotypic screening), and once activity is gleaned, the protein target is experimentally identified by target deconvolution [2].
Thus, these data suggests that the matrix-producing sessile opaque bacteria may exhibit a phenomenon specific to some experimental models or cell types.
Many studies at molecular levels have focused on the use of animal models or cell cultures for understanding mercury toxicity.
The safety of food additives is usually examined by varying the dose of a single additive administered to animal models or cell cultures.
To date, few transporter studies have been conducted in the setting of AKI, and all that have been conducted have been in animal models or cell cultures.
In order to assess the pathogenicity of specific MYO1E mutations, it is important to determine the effects of these mutations on myosin 1e activity, a task that can be challenging to perform in animal models or cell cultures.
Similar to laboratory experiments with real cells, different studies using computational models (or virtual cells) also require the set up of optimal extracellular conditions.
Still, the promoter silencing appears to be model or cell type dependent, as tumors in the SCLC model showed robust Luciferase expression judged by the exponential increase in luminescence signals measured in the majority of the invCAG-Luc Rb1 invCAG-Luc Rb1 chimeras (F/F 4B).
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