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Models of viral evolution are thus improving their accuracy and becoming more competent from a conceptual and a predictive viewpoint.
2004, 18, 739] constructed models of full-length HIV-1 integrase complexed with models of viral and human DNA.
A major unknown factor in constructing realistic models of viral evolution is how mutations affect fitness, which amounts to unveiling the nature of viral fitness landscapes.
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This modeling framework presents an example of how an implicit mapping can be made from genotype to a fitness parameter important for viral biology, i.e., viral capsid yield, with potential applications to theoretical models of viral evolution.
Mathematical models of viral dynamics have been successfully used to study HIV infection [25].
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Natural models of viral-induced tumorigenesis provide an excellent opportunity to analyze mechanisms of transmission, transformation, viral persistence, and routes of shedding and infection.
In animal models of viral-induced demyelination, such as distemper, inflammatory white matter lesions result at least in part from the intrathecal immune response against the virus, which in the case of CDV infects predominantly astrocytes [ 39, 43].
To this end we use a detailed modeling approach in which we combine an intra-cellular model of viral growth and the RNA silencing pathway with inter-cellular tissue dynamics.
We used an immune activation model in juvenile monkeys where poly I C was administered as an experimental model of viral infection.
Intranasal application of vesicular stomatitis virus (VSV) produces a well-characterized model of viral encephalitis in mice.
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