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Notably, findings from few existing (clinically relevant) mouse models of trauma and sepsis parallel, at least partly, the aforementioned clinical findings.
Overall, the findings support established models of trauma memory processing [24], [25], [26], [55].
Finally, organisational and administrative models of trauma centres may influence compliance with guidelines [ 19].
Animal models of trauma have their limitations, and the findings in animals may not directly mimic the situation in trauma patients.
This article will focus on the effect of blood loss and surgical injury on cell-mediated immune responses in experimental studies utilizing models of trauma and hemorrhagic shock, which have defined effects on the immunoinflammatory response.
20 Although evidence-based ideal models of trauma care have been described, 11 20 service providers' understanding of trauma patients' needs, their perspectives on real world provision and how services can better meet the needs of patients are largely unknown.
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Implications for theoretical models of trauma-related rumination and possible clinical implications are discussed.
Induced hypothermia seems to reduce the mortality in experimental models of trauma-haemorrhage.
Furthermore, the observation time has to be considered when interpreting the effects of hypothermia found in porcine models of trauma-haemorrhage.
This review aims to elaborate the differences between accidental and induced hypothermia and to summarize the current knowledge of the potential therapeutic use of induced hypothermia suggested in porcine models of trauma-haemorrhage.
As the maintenance of clot strength has been shown to be crucial for transfusion requirements [36], it is tempting to speculate that the effects of therapeutic hypothermia on the coagulation system are rather limited - at least in porcine models of trauma-haemorrhage [40].
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