Sentence examples for models of tau from inspiring English sources

This commentary will discuss the use of immunotherapy for AD, focusing on tau immunotherapy in the context of recent reports on the use of tau phospho-peptides in transgenic models of tau pathology.

To conclude, until now, only in vivo models of Tau capture [ 12, 48] and/or Tau secretion have been developed [ 21].

In animal models of tau protein, such as P301Stau transgenic mice, someone found that there gathered a large number of reactive microglia surrounding tau protein nerve cells [ 37].

We treated rTg4510 mouse models of tau deposition and non-transgenic mice with tubastatin (25 mg/kg) or saline (0.9%) from 5 to 7 months of age.

Other models of tau propagation used either a tau infusion paradigm similar to the one used here [ 9, 26, 30] or the region-specific expression of human mutant tau [ 12, 33].

Although this may be true in part, the results of this study and other in vivo models of tau propagation [ 9, 12, 26, 30, 33] highlight the ability of tau to affect whole neuronal networks as opposed to isolated neurons/nuclei.

In their experiments in neurons from patients with Alzheimer's disease and in cellular models of tau-based neuropathology, the researchers found that the Alzheimer's-associated form of tau, which is studded with phosphate molecules, directly interacts with an important nucleoporin called Nup98.

He has used new imaging technologies to map — for the first time — the three-dimensional atomic model of tau tangles inside the brain, as published in 2017 in the journal Nature.

Moreover, in a transgenic mouse model of tau pathology, we observed that isoflurane-induced hypothermia accelerates neurofibrillary pathology [17].

The first in vivo model of tau propagation showed a similar induction of tau pathology.

A suitable animal model of tau mis-splicing to evaluate SMaRT in neurons is the htau mouse.