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Animal studies using models of surgically induced extrahepatic biliary obstruction have also shown that lipid peroxidation products – specifically, malondialdehyde (MDA) – are increased in the cholestatic liver [ 8, 9].
7, 13– 19, 19, 20 Behets et al, 13 Calvo et al, 14 El Hajjaji et al, 15 and Intema et al 20 analyzed the bone-characteristic changes in OA using animal models of surgically induced secondary OA, generally by performing anterior cruciate ligament transaction or menisectomy.
A large number of research articles have demonstrated the efficacy of cannabinoids and modulators of the EC system in the alleviation of neuropathic pain in various animal models of surgically induced trauma, such as chronic constriction injury, partial sciatic nerve ligation, or spinal nerve ligation [ 14, 36].
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Indeed, anterior cruciate ligament transection or destabilisation of the medial meniscus are used in animal models of surgically-induced osteoarthritis [ 3].
We have previously reported the characterization of the morphological and histological changes in cartilage and subchondral bone in two different models of surgically-induced OA in the rat, the anterior cruciate ligament transection (ACLT) model or the ACLT in combination with partial medial meniscectomy (ACLT+MMx) [ 16].
To define the altered gene expression profile of endometriotic lesions in a mouse model of surgically induced endometriosis.
To date, FGF-2 has been reported as efficacious in regenerating periodontal tissue in models of artificial defect of periodontal tissue in beagles and non-human primates (Macaca fascicularis) and in a model of surgically created periodontitis in beagles [13] [15].
We used an established mouse model of surgically induced endometriosis to measure levels of CECs and EPCs.
18 A rat model of surgically induced EMs involves auto-transplantation of biopsies of uterus in the abdomen, 19 which is widely used in the research of EMs.
In this study we examined the blood levels of EPCs and mature circulating endothelial cells in a mouse model of surgically induced endometriosis.
Although ADAMTS-4 expression is upregulated in human OA, only the lack of ADAMTS-5 prevented cartilage degradation in a mouse model of surgically induced OA [ 80].
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