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A priori knowledge about physical or chemical properties of nucleotide or amino acid residues can be used to define mechanistic models of substitutions.
Similar estimates of branch lengths were obtained for different models of substitutions (Table S4) suggesting that the obtained results are reliable.
We hereby present a general implementation of non-homogeneous models of substitutions.
The information from the review describes experiences with models of substitutions that have been used in African countries.
Phylogenetic trees based on aligned nucleotide sequences of selected subgroups of Rab proteins were inferred in the TreeFinder [ 140] and MrBayes 3.1.2 programs [ 141] assuming separate models of substitutions GTR+I+Γ or GTR+Γ for three codon positions.
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Three models of substitution are analyzed.
Models of substitution: ITS2 = GTR with ITS2 substitution matrix, Modeltest: TVM+I+G with estimated parameters.
Codon partition models allow for different models of substitution for different partitions of the data.
Parameters of the substitution model were determined by running jModeltest (Posada 2008) to test 56 different models of substitution.
Models of substitution applied in the dating analysis (4 partitions, PartitionFinder).
Appropriate protein models of substitution were selected for each gene family using ModelGenerator [ 75].
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