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Reddy, D. S. & Kuruba, R. Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventions.
Models of status attainment developed in Wisconsin in the 1970s considered social psychological factors as well as intelligence and education.
The difference was these were models of status transmission from parents to children; they sought to explain why inequalities persist, not the exceptions when they do not.
Previous studies have reported that valproate can be neuroprotective, both for cells grown in culture and as well as in a rodent models of status epilepticus and ischemic stroke [42], [43], [52].
In our previous study, we used pilocarpine, another cholinergic neurotoxin, to induce experimental models of status epilepticus and found that pilocarpine induced two types of seizures: severe prolonged seizures and repeated seizures [ 22].
Apoptosis, or programmed cell death, has been shown to be responsible for a significant component of seizure-induced neuronal loss in different animal models of status epilepticus (SE), and these pathways are also regulated in human TLE.
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With this argument, we use a computational modeling approach combined with in vivo electrophysiological data obtained from an experimental model of status epilepticus to infer about changes that may lead to a seizure.
A new model of status epilepticus has been developed in the unanesthetized rat.
A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus.
It is also possible that the changes could be a result of frequent seizures with secondary neuronal loss and appearance of clusters of adjacent cells in layer II; a similar pattern of neuronal loss has been seen in an animal model of status epilepticus [Roch et al., 2002].
In particular, the expression of miR-155, an inflammatory modulator, is significantly increased in the brain in an immature rat model of status epilepticus and in children with MTLE [ 12], suggesting that the inflammatory role of miR-155 is involved in the development of early-onset epilepsy.
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