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Although several animal models of sleep apnea have been described previously, mice would be useful experimental animals in that these animals are frequently used in genetic engineering.
Models of sleep deprivation have demonstrated that the amount of sleep following deprivation does not correlate with the amount of locomotor activity during deprivation [8].
Intermittent hypoxemia has been shown to be toxic to β-cell function in murine models of sleep apnea (31, 32).
More generally, the presence of mammalian-like activity in the avian brain, despite differences in neuronal cytoarchitecture, suggests that the apparent absence of similar sleep-related activity in prominent invertebrate models of sleep, such as Drosophila melanogaster[ 50], cannot be simply attributed to their lack of a neocortex.
Studies of the effects of sleep loss have mostly included healthy volunteers, and the studies apply models of sleep loss that may not be directly applicable to the critically ill patient; regardless, these sleep-deprived individuals have shown all of the clinical manifestations of hypoactive (quiet) delirium.
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Moreover, few attempts have been made to incorporate ultradian rhythmicity into models of sleep-wake regulation.
Our results point to the importance of various sleep mechanisms such as sleep spindle-related alpha power or NREM REM ratios rather than supporting classical dual-process or dual-step models of sleep-dependent memory consolidation.
This quadriphasic model of sleep is now obsolete, in view of the new study in which sleep is broken down into seventeen distinct stages.
"The consolidated model of sleep is predicated upon the solidification of other institutional times in American society, foremost among them work time," he writes.
In the early 1980s, Dr. Alexander A. Borbély, a professor of pharmacology at the University of Zurich, Switzerland, posited a "two-process model of sleep regulation".
6. Art Winfree proposed the deliberately simplified model of sleep duration discussed above, in "Impact of a Circadian Clock on the Timing of Human Sleep," American Journal of Physiology, Vol. 245, No. 4 (Oct . 1983, pp. R497 R504.
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