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http://code.google.com/p/netflux/ CellNOpt Free software for creating logic-based models of signaling networks.
Knepper's lab builds models of signaling networks by identifying specific protein kinases and phosphatases.
Given the experimental costs of exhaustively testing drug combinations, computational models of signaling networks will be especially useful in pre-clinical screening of combinations of compounds.
www.cytoscape.org Computational modeling Netflux Modeling and simulation tool for construction of normalized-Hill models of signaling networks from user defined species interactions.
At the molecular level they have been mainly used to build models of signaling pathways that account for spatial distribution and the structural properties of the cell (Gonzalez et al. 2003, Pogson et al. 2006; 2008, An 2009).
We expect that in the future the platform will be applied to develop comprehensive models of signaling networks and will help to investigate the mechanism of action as well as side effects of therapeutic treatments.
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Kinship is central to models of signalling between relatives, for instance when broods of nestling birds beg and compete for food from their parents.
Furthermore, most computational models of signalling pathways relate to events in a 'typical' cell.
Here, we consider models of signalling though the erythropoietin receptor (EpoR), transduced by STAT5 (Fig. 4a) (Darnell, 1997; Horvath, 2000).
An excellent review regarding the modeling of signaling pathways was elaborated by Aldridge et al. (2006).
A kinetic ternary-complex model of signaling through G-protein coupled receptors is presented.
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