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Experimental evidence and related models of sensitization, exposed in the previous paragraph, can be applied to migraine, postulating that the sensitization process, which eventually results in allodynia and hyperalgesia, initiates at peripheral sites.
These two animal models of sensitization can produce an IgE-dependent intestinal allergic reaction yielding an anaphylaxis-dependent increase in intestinal permeability [ 5, 14].
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The increased sensitivity of cranio-cervical sites supports the neurophysiological model of sensitization in migraine and chronic TTH.
These significantly lower PPT thresholds in the trapezius muscle and suboccipital sites reflect altered pain perception in this regions and support the pathophysiological model of sensitization in migraine and chronic TTH [32].
This neurophysiological model of sensitization of the trigemino-cervical nucleus caudalis is generally presumed to play an important role in the onset and maintenance of chronic headaches including migraine and chronic tension-type headache (TTH) [7, 8].
We previously reported the potential of bronchoalveolar lavage fluid (BALF -derived tolerogenic exosomes (ExoTol) to BALF -derivednasal allergy vaccine in a mouse model of sensitolerogenic OlexosomeshExoTol allergen of olive pollen.
The data showed that the UNICEF model of sensitization is efficient in creating awareness of base-level understanding of AL, but not in creating authentic AL environments in schools.
Koltsida and colleagues utilized mice deficient in the IL-28Rα chain, administration of exogenous IL-28A and infection with adenovirus encoding IL-28A in a mouse model of sensitization and challenge to the egg allergen ovalbumin (OVA) to investigate the role of IFN-λs in allergic airway inflammation.
Such information will enhance our understanding of the molecular processes involved in allergic contact dermatitis and may provide a mechanistic basis for designing refined animal and in vitro alternatives to existing models of skin sensitization.
We used two models of locomotor sensitization in this study, a two-injection protocol [21] and a repeated drug injections protocol (Fig. 1).
Most models of epicutaneous sensitization use the model allergen ovalbumin (24, 25), intradermal or subcutaneous allergen application (26– 26).
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