Sentence examples for models of receptor from inspiring English sources

We compare in detail the activity response of coupled two-state receptors for different models of receptor coupling: weakly-coupled extended one-dimensional and two-dimensional lattice models and the Monod-Wyman-Changeux model of isolated strongly-coupled clusters.

We find that the fluorescence resonance energy transfer results for wild-type and for a low-activity mutant are inconsistent with the lattice models of receptor coupling, but consistent with the Monod-Wyman-Changeux model of receptor coupling, suggesting that receptors form isolated strongly-coupled clusters.

According to allosteric ternary complex models of receptor activation [20], V2R, like all GPCR, exists in an equilibrium between inactive and active conformations.

To date various models of receptor and ligand deletion have been reported [ 12].

Models of receptor point mutants were prepared by side chain substitution in previously prepared homology models and then subjected to energy minimization prior to ligand docking.

It should be stated that the model parameters for receptor internalization and recycling are from the same source as the experimental data sets in Figure 4. Backer et al. took the experimental data sets to estimate the parameters for two separate models of receptor internalization and recycling at 100 nM insulin as well as without insulin [ 34].

Like in the previous models of receptor-mediated adhesion [14], for the initial point contact to begin developing into a significant cell-cell interface area in our model, the local receptor density P must be above pcrit.

Mathematical modeling of receptor activation based upon our biophysical studies shows that ligand pulses are "buffered" at low receptor levels, leading to a sustained signal.

Different studies have presented a multistate model of receptor activation in which ligand-specific receptor conformations are able to differentiate between distinct signalling partners.

According to the traditional two-state model of receptor theory, GPCRs were considered as operating in equilibrium between two functional conformations, an active (R*) and inactive (R) state.

The two-state model of receptor activation has given way to multistate models with intermediate conformational states.