Sentence examples for models of prion from inspiring English sources

The peripheral distribution of PrPSc has been well characterized in rodent models of prion diseases [32], [33].

This fact is also known from rodent models of prion infection [31], but had never been demonstrated in primates before.

With our study we show that the intraperitoneal route, which is widely used in rodent models of prion diseases, is also effective in transmitting prion diseases in primates.

To ascertain whether LSPC knockdown of PrPC expression sufficed to cure prion infection, we used two cell culture models of prion infection.

In conclusion, we have developed a procedure for obtaining pure preparations of aggregated PrP from different mouse models of prion disease, even those that accumulate abnormal forms of PrP that lack infectivity and/or protease resistance.

Because expression of the human immunodeficiency virus-1 (HIV-1) gag gene in cultured cells promotes formation of PrPSc in the cell culture models of prion disease [47], we assessed whether HIV-1 Gag influences in vitro amplification of PrPSc.

Using the ME7 model of prion disease, Cunningham and colleagues demonstrated that the primed brain showed exaggerated response to several challenges, including LPS, poly I C, IL-1β, and TNF-α [89 91].

Modeling of prion diseases has contributed and will continue to contribute to the understanding of the pathogenesis as well as of the therapeutics of these diseases, but crucial experiments remain elusive.

However, a model of prion replication must explain both how prions propagate, and why their spontaneous appearance is so rare.

Tissues from the RML murine model of prion pathogenesis were collected at various stages throughout pathogenesis.

C57Bl/6 mice inoculated with the Me7 prion strain are an effective model of prion diseases that have been well described for their incubation time, vacuolization profiles, and immunohistology [34], [35].