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In experimental models of pneumococcal meningitis, dexamethasone increased neuronal damage in the dentate gyrus.
Several vaccine formulations based on PspA have proven to be effective in animal models of pneumococcal infections.
Pneumococcal surface protein A (PspA) is among the best-characterized pneumococcal antigens that confer protection in animal models of pneumococcal infections and, as such, is a good alternative for the currently available conjugated vaccines.
In well-controlled animal models of pneumococcal pneumonia, statins have been shown to improve survival [ 3].
No benefit of adjunctive glycerol was found in these models of pneumococcal meningitis.
For comparison, CSF Ply levels in animal models of pneumococcal meningitis were 20 ng/mL−1 of CSF [ 4].
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Using two Streptococcus pneumoniae proteins as model antigens, we showed that intranasally administered Salmonella OMVs displaying high levels of antigens at the surface induced strong protection in a murine model of pneumococcal colonization, without the need for a mucosal adjuvant.
We designed this study to assess the therapeutic potential of simvastatin in an established animal model of pneumococcal meningitis, a disease characterized by high morbidity and mortality despite effective antibiotic treatment.
Our data suggest that the difference in the relative virulence of Spn opacity phenotypes is associated with its ability to evade complement-mediated opsonophagocytosis in a mouse model of pneumococcal AOM.
We developed a mathematical model of pneumococcal colonization in a partially vaccinated community (Figure 1).
A virulent S. Pneumoniae strain capsular type 6A DBL6A was used in an experimental model of pneumococcal infection passive of meningitis.
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