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It is increasingly clear that multiple mechanisms of varying hierarchy and importance are involved in persister formation in different models of persistence (Table 3).
Often frustrated, occasionally triumphant, they are models of persistence and perseverance.
Three models of persistence of duplicated genes are commonly encountered in the literature.
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It is important to establish more relevant models of persisters or persistence for mechanistic studies that are representative of in vivo situations, as well as developing drugs that kill in vivo persisters and improve treatment.
At the same time, he was a model of persistence.
Although in past, hypoxia induced model have been used for compound screening but only AID-488890 has been used to study carbon starvation model of persistence.
Mycobacterial behaviour within adipocytes may be interesting to further investigate as a model of persistence, as compared to other currently used in vitro models of mycobacterial dormancy.
The physiology of hypoxic non-replicating M. tuberculosis has been studied in vitro in the Wayne model of persistence in which mycobacterial cultures are subjected to self-generated oxygen depletion in sealed containers [7].
This definition was based on the refill-sequence model of persistence, which has been described previously [ 31].
A previous model of persistence has shown that the optimal frequency of persistence events is closely tied to the frequency of environmental change [ 37].
This model of persistence in established disease requires the presence of hyperplastic synovial tissue, which is unlikely to be present at the onset of RA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com