The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation.
Anti-E-selectin antibody labelled with NIR fluorophore has demonstrated specific signal increases compared to control antibody in a mouse model of paw swelling induced by the intra-plantar injection of TNF-α.
Here we use an experimental model of rat paw oedema formation to examine the effect of exogenously added histamine on the gene expression of H1R and bradykinin receptors B1R and B2R, alone or in combination to rupatadine, a second generation antihistamine agent.
To determine a preclinical dosage regimen for cimicoxib in dog, a reversible model of kaolin induced paw inflammation was used.
In a xenotransplant model of 4T1 paw cells in BALB/c mice, an increase in tumor size was recorded following Δ 9-THC (25 mg/kg, intraperitoneally, 21 days).
In CFA induced rheumatoid arthritis model, the inhibition of paw edema was significantly higher (73.85 ± 14.5%).
The anti-inflammatory efficacy was evaluated in carrageenan induced paw edema and FCA induced arthritic rat model in terms of paw swelling, weight indices of the liver and spleen, pathological changes in nuclear factor kappa B, iNOS, COX-2 expression and inflammatory cytokines.
In animal models of carrageenan-induced paw edema or cerebral ischemia, administration of fetuin-A merely attenuated early, but not late, inflammatory response in the paw [42] or ischemic brain [43].
Among many animal models of inflammation (sponge implant, paw edema, peritoneal, pleurisy, and air pouch), the air pouch model has the advantage of not involving internal organs, which can be damaged or perforated during sampling [21].
The analgesic and antiarthritic activities of piperine were investigated on rat models of carrageenan-induced acute paw pain and arthritis.
