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These studies also indicate a central role of CD4+ T cells in CD pathogenesis and point to B cells as important players, which is in accordance with the key steps highlighted by the immunological models of pathogenesis.
This hypothesis is also consistent with the centrality of mitochondria in prevailing models of pathogenesis in PD, as it serves as one of the primary sources of Ca++ buffering.
These facts suggest differences between models of pathogenesis of lyssavirus infections in bats.
Further weakening arguments for causal associations is the absence of well-defined plausible models of pathogenesis.
3 Traditional models of pathogenesis have suggested that early vascular events associated with autoimmunity and inflammation lead to subsequent fibrosis.
To address these and other possible models of pathogenesis, we studied a Drosophila strain with a mutation affecting the mitochondrial-encoded respiratory chain complex I subunit ND2.
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Cherry, S. & Perrimon, N. Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis.
Jones, T. I. et al. Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis.
The 'two-hit' model of pathogenesis was proposed in 1998, with the first 'hit' – steatosis – increasing the sensitivity of the liver to the second 'hits' mediating liver injury.
Human surgical tissues are often beyond this initial stage and there is no published murine model of pathogenesis, to study the natural history of the disease.
To develop a model of pathogenesis by which Chlamydia trachomatis progresses from acute to chronic infection, and finally serious disease (salpingitis, tubal occlusion).
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