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Similar observations were made for synthetic models of optic chiasms of a human and a hooded seal which were opposed to experimental 3D-PLI data sets obtained from the chiasms of both species.
In order to investigate the progress in optic nerve injury and the following regeneration and repair, many kinds of animal models of optic nerve injury have been established, such as models of acute and chronic ocular hypertension, compression, amputating wound, ischemia reperfusion or hypoxia, intravitreal injection of excitatory amino acids, etc.
In addition, BMD provides neuroprotective effects in various animal models of optic neuropathy including experimental glaucoma, ischemia, oxidative stress and optic nerve injury.
Brimonidine, an α2-adrenergic receptor agonist, and widely used ocular hypotensive agent, has been reported to protect against RGC death in rodent models of optic nerve crush, acute retinal ischemia and glaucoma [ 4- 8].
Earlier studies in models of optic nerve or spinal cord white matter anoxia showed that VOCCs participate in CNS white matter hypoxic injury (Fern et al., 1995; Fern, 1998; Imaizumi et al., 1999).
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To investigate the process of secondary degeneration and ways to prevent it, we designed a well-calibrated model of optic nerve crush injury.
We have developed a Drosophila model of optic atrophy [18].
Activation of SIRT1 using other non-commercially available compounds has also been reported to be neuroprotective in a model of optic neuritis [22].
Furthermore, in a model of optic neuritis, the acute immune response leads to an adaptive, specific, anti-brain response [ 17– 17].
Our present results also showed that the cuprizone-induced demyelination model is useful as an animal model of optic neuritis, like EAE.
In this study, we examined the effects of spermidine on retinal ganglion cell (RGC) death in a mouse model of optic nerve injury (ONI).
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