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More recently, new methodologies of gene editing have been developed, providing new transgenic animals models, including knockout and knockin models of mice and other animal species.
There are genetic models of mice that have abnormalities with drinking.
We evaluated the use of optimized consensus influenza antigens to provide broad protection against divergent strains of H5N1 influenza in three animal models of mice, ferrets, and non-human primates.
In order to analyze the over-expression of DYRK1A on plasma Hcy levels, we used three models of mice, which overexpress not only the murine gene, but also the human one.
The transcript levels of PGC-1α are dramatically decreased in models of mice with muscle atrophy induced by denervation and diabetes [45], while energy restriction enhances the expression of PGC-1α in skeletal muscle of rodents and humans [46] [48].
This observation is in accordance with the previous descriptions of other Card15/Nod2 KO models of mice which failed to reveal gross intestinal abnormalities under basal conditions [7], [25].
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Calculations were performed for the models of mouse, rat and man.
The Mouse Brain Web (MBW), a web-organized database, provides for the construction of anatomically correct models of mouse brain networks.
Other researchers like Parsons and Sera et al. have utilized IL-XPCI to study lungs, and successfully generated the three-dimensional models of mouse airways [7], [17].
In two different models of mouse SSc, importance of IL-17 was suggested.
This takes advantage of sophisticated 3D computer models of mouse anatomy and histology across different developmental stages.
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