PGC-1α is closely related to FFA metabolism, and its expression level changes in various tissues in rodent models of metabolic disorders [17], [25].
The self-sufficiency case has also been studied implicitly in models of metabolic trade.
In light of the described pathogenic role of RGS16 in hepatic steatosis35, we further interrogated whether Arg2 and RGS16 anti-correlate in multiple models of metabolic disease.
A team led by Associate Professor Dennis Vitkup has received a multiyear grant to develop models of metabolic networks for all of the major bacterial species that cause disease in humans.
A novel approach to construct kinetic models of metabolic pathways, to be used in metabolic engineering, is presented: the tendency modeling approach.
Here, we outline network topologies that have been successfully validated in animal models of metabolic diseases and discuss future developments that will be important for bringing this technology closer to clinical application.
In this review we discuss recent developments in knowledge-based metabolic engineering strategies, that is the gathering and mining of genomic, transcriptomic, proteomic and metabolomic data to generate models of metabolic pathways that help to define and refine optimal intervention strategies.
Animal models of metabolic disease may provide some clues to the connection between obesity and vascular inflammation.
With reference to other cardiovascular risks also associated with CVD and metabolic syndrome, protection against the development of impaired glucose homeostasis and insulin resistance has been reported in animal studies, especially in murine models of metabolic syndrome and type-2 diabetes.
Plant databases like Gramene (Jaiswal 2011; Monaco et al. 2013), Kyoto Encyclopedia for Genes and Genomes (Masoudi-Nejad et al. 2007a; Masoudi-Nejad et al. 2007b), Arabidopsis Reactome (Tsesmetzis et al. 2008; D'Eustachio 2010), MetaCyc (Caspi et al. 2012) and Plant Metabolic Network (Zhang et al. 2010) are good integrated resources to study the models of metabolic pathways.
Likewise, numerous works have been carried out on the mathematical models of metabolic rhythms [1], [6], [8], [and 34].
