These results are consistent with those obtained by Salameh et al. (2007) and Yin et al. (2007b) using animal models of liver fibrosis and MR elastography.
A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease.
Fouts, D. E., Torralba, M., Nelson, K. E., Brenner, D. A. & Schnabl, B. Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease.
This project will be facilitated by my experience with PSC differentiation, assays of liver cell identity and function, and mouse models of liver failure.
To this end, mouse models of liver injury enable the evaluation of human hepatocytes and their behavior upon transplantation into a complex injured liver environment.
In vitro models of liver physiology have been developed and new technologies and approaches are progressing rapidly.
In particular, I have focused on generating pure populations of liver progenitors from PSCs; these PSC-derived human liver progenitors regenerated human liver tissue, and improved the survival of, mouse models of liver failure (Ang et al., 2018; Cell Reports).
This Core facility provides technical expertise, equipment and personnel to Liver Center Investigators who wish to work with animal models of liver disease, isolated liver cells, or gene expression in liver tissue.
The few reported experimental models of liver trauma use the "clamp and crush" mechanism of injury and do not cause reproducible liver injury.
This review discusses existing in vitro and animal models of liver metastasis, which are unique and practical models for investigating the mechanisms underlying tissue-specific metastasis.
Both anti-fibrotic and pro-fibrotic properties of mesenchymal stromal cells (MSCs) have been described in various animal models of liver fibrosis.
