Sentence examples for models of leukemia from inspiring English sources
In mouse models of leukemia and melanoma, IDH mutants accelerated cell cycle transition by activation of the MAPK/ERK pathway and repression of tumor suppressors CDKN2A and CDKN2B (Chaturvedi et al., 2013; Shibata et al., 2011).
Here I review three noteworthy applications of fluorescent proteins in zebrafish: (1) analysis of kinesin motor function in the cleaving zebrafish embryo, (2) determination of the roles of semaphorins in axonal guidance, and (3) creation of transgenic models of leukemia and other cancers.
In several models of leukemia, acadesine has been reported to trigger AMPK activation, an effect accompanied by an important inhibition of their proliferation potential.
Using murine experimental models of leukemia and orthotopic breast cancer, we show that low-dose IR promotes tumor growth and metastasis and that these effects were prevented by the administration of a VEGF receptor-tyrosine kinase inhibitor immediately before IR exposure.
This histology resembles that of existing zebrafish models of leukemia (Langenau et al., 2005; Chen et al., 2007).
To investigate the antitumor effects of selenite in vivo, xenograft models of leukemia NB4 cells were established as described in the Materials and Methods.
In our previous work in a xenograft model of leukemia, we compared two T cell manufacturing methods that are commonly used in adoptive immunotherapy clinical trials, CD3/CD28 Dynabead and OKT3/IL-2.
Similar ambivalent modes of action were identified recently for p21/WAF1 in a mouse model of leukemia [50].
The question arises: Is it possible to translate the observations of DAC in this mouse model of leukemia to the clinical treatment of patients with leukemia?
Lastly, we demonstrate that MerTK inhibition sensitizes leukemia cells to treatment with chemotherapeutic drugs, and reduces their leukemogenic potential in a xenograft mouse model of leukemia.
B7-H1 partinipathe immunoescapeofscancerf cellsr cells and is also involved in the long-term persistence of leukemic cells in a mouse model of leukemia.
