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First, a deeper corelation is required to be established between its anti-inflammatory and anti-infective reactions through the in vivo models of infections.
Several mathematical models of infections are proposed and investigated.
We have developed several models of infections in wounds and soft-tissue abscesses in mice that can be followed by bioluminescence imaging.
The difference between the outcomes seen in these studies and the one presented here is likely due to different models of infections and viruses used, respectively [36].
Capsule plays a role in the virulence of S. suis; type 2 capsule mutants are avirulent in murine and pig models of infections [43], [49] The capsule itself can mediate prostaglandin E2 (PGE2) and matrix metalloproteinase 9 (MMP-9) production by human macrophages [50] suggesting a role in pathogenesis of disease.
Notably, in animal models of infections with such organisms, treatment with cefepime has produced both successful and unsuccessful therapeutic outcomes.
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Mouse and nonhuman primate models of infection demonstrated that the emerged clone is unusually virulent.
Archaeosome vaccines provide profound protection in murine models of infection and cancer.
This may be partly due to the difficulty of monitoring the effectiveness of PDT in animal models of infection.
An early objective was assessment of vaccine efficiency, and models of infection remain central to current work in this area.
WRSf2G12 and WRSf2G15 are genetically stable and highly attenuated in both cell culture and animal models of infection.
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CEO of Professional Science Editing for Scientists @ prosciediting.com