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However, despite early findings in feeding and appetite control, orexin receptor antagonists have not produced the anticipated effects in models of increased food intake or obesity in rodents, nor have they shown marked effects on weight in the existing clinical trials.
In the case of one of the most clinically relevant models of increased fat mass in mice (OB/OB), the rate of preadipocyte replication is significantly increased, supporting the idea that the development of obesity is due to both an increase in fat cell size and fat cell differentiation[2], [3], [4].
This is in agreement with increased UPR activation in models of increased A53T mutant [ 156, 160] or wild-type [ 157, 159] and phosphorylated α-synuclein [ 158] expression.
The antioxidant activity of -thioctic acid is also loftier than the racemic mixture of the compound in cellular models of increased oxidative stress [ 20].
The demonstration that two models of increased longevity and stress resistance share metabolic phenotypes and genotypes, and also with aging models from lower organisms, will provide direction for future research, with the goal of developing novel therapeutic approaches.
However very low light (and associated low growth) in the wild may contribute to seedling mortality by fungal pathogens, herbivory, litterfall and drought, in line with models of increased juvenile risk in slow-growing species (Bond 1989).
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Table 3 shows the results of the hierarchical modeling analyses for four models of increasing complexity, which are shown in separate columns.
The proposed modelling approach results in three motor models of increasing complexity independently of the low-level piezoelectric properties of the driving elements.
We identify three cases of connection models of increasing complexity.
In total, two models of increasing complexity have been employed.
A generic model is described and three different particular models of increasing complexity are analyzed.
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