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In this Review, we discuss the use of rodent models of impulsivity, particularly in relati on to the endogenous expression of impulsive behaviour (referred to here as trait or trait-like impulsivity), for investigating the underlying mechanisms of this behaviour and its potential aetiological relationship as an endophenotype of the pathogenesis of addiction.
Here, we review the use of rodent models of impulsivity for investigating the mechanisms involved in this trait, and how these mechanisms could contribute to the pathogenesis of addiction.
Tests used on rodent models of impulsivity share strong parallels with tasks used to assess this trait in humans, and studies in both suggest a crucial role of monoaminergic corticostriatal systems in the expression of this behavioural trait.
Further studies are needed to address other aspects of impulsive-related psychopathologies, but the strategy proposed here will help to define behavioural substrates required for animal models of impulsivity and to explore their neurobiological bases more accurately.
Animal models of impulsivity have provided significant insight into the underlying neurobiological, genetic and environmental contributions to impulsivity as a behavioural endophenotype, and as a susceptibility marker for addiction.
This review describes and evaluates some of the current behavioral models of impulsivity developed for use with rodents based on human neuropsychological tests, focusing on the five-choice serial reaction time task, the stop-signal reaction time task and delay-discounting paradigms.
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Barratt proposed a three-factor model of impulsivity: motor, attention and impulsivity by lack of future planning.
A multi-faceted model of impulsivity was adopted to explore how different facets may relate differently to BD.
The current study assessed whether the two-factor model of impulsivity (Dawe & Loxton, 2004) predicts a preference for supernormal stimuli.
For example, Whiteside and Lynam (2001) factor-analysed several widely used self-report impulsivity measures resulting in their four-factor model of impulsivity: 'lack of premeditation', 'lack of perseverance'sensationion seeking' and 'urgency'urgency
Barratt et al. (Patton et al. 1995; Stanford and Barratt 1992) considered self-ratings, behavioural tasks and animal research resulting in a three-factor model of impulsivity: 'attentional'motortor' and 'non-planning' impulsivity, leading to the development of the Barrett Impulsivity Scale (BIS).
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