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Our models assume immobilization is a global effect, affecting all CD2 epitopes; we make this assumption because localized models of immobility yield equilibrium behavior identical to the fully mobile model, which does not fit our data.
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In the mouse model of OA, immobility induced by prolonged anesthesia or by sciatic neurectomy prevented OA up to 12 weeks postsurgery [ 45].
The health benefits conferred by SRT2104 led us to determine whether short-term treatment could offer protection against disuse atrophy of muscle and bone that occurs in an experimental model of prolonged immobility.
Methanol extract of H. tiliaceus significantly decreased the duration of immobility in both animal models of antidepressant activity, forced swimming and tail suspension tests.
The forced swimming and tail suspension tests were used as predictive animal models of antidepressant activity, where the time of immobility was considered.
For example, I faced a situation of immobility and pain with my hip dysplasia.
Our model incorporates immobility of epitopes, potential nonspecific adhesion forces, heterogeneities in target cell epitope density, and the possibility that ligand binding or adhesion alters the immobile epitope fraction.
+++ = reduced highly, ++ = reduced moderately, + = reduced slightly, DMSO = dimethyl sulfoxide, NE = no noticeable effect on motility even after 60 min. It should be noted that in the in vitro model, complete immobility of parasites does not necessarily mean that the parasites are dead, but rather the parasites may have lost their infectivity.
Onset of immobility (behavioural despair) in the latter model is defined as the point at which the animal stops struggling for longer than 1 second.
The shortening of immobility duration indicates antidepressant activity in this model, while prolonged immobility time reflects a CNS depression-like effect [35].
Gpr3−/− mice exhibited an increase in the duration of immobility compared with wild-type mice in both behavioral models.
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