In rodent models of high-fat diet-induced obesity, leptin resistance is seen initially at vagal afferents, blunting the actions of satiety mediators, then centrally, with gastrointestinal bacterial-triggered SOCS3 signaling implicated.
Rodent models of high-fat-diet (HFD) induced obesity have been well accepted as important research tools that provide a window into disease pathogenesis and useful preclinical models for investigation of novel interventions for obesity treatment [ 12].
This potential of Nrf2 to play a role in cell metabolism has also become evident from studies in murine models of high-fat diet-induced obesity and methionine choline-deficient diet (methionine choline-deficientease.
In our model, early life signals of high fat nutritional conditions led to accelerated maturation.
Logistic regression models were built to compare the odds of high fat scores for cases and controls with adjustment for confounders.
The aim of this study was to assess bone microarchitecture and turnover in a mouse model of high-fat diet induced obesity.
To investigate the effects of specific retinoic acid receptor (RAR) agonists in diabetes and fatty liver disease synthetic agonists for RAR beta 2 were administered to wild-type (wt) mice in a model of high-fat-diet (HFD -induced type 2 diabetes (T2D) and to ob/ob and db/db mice (genetic models of obesity-associated T2D).
DESIGN: Survey of adipose tissue betaAR expression from four mouse models of congenital obesity: the 'obese' mouse (C57BL/6J Lep ob)/Lep ob)), the 'diabetic' mouse (C57BL/KsJ LepRdb/LepRdb), the 'tubby' mouse (C57BL/6J tub/tub) and the 'fat' mouse (C57BL/KsJ Cpe(fat)/Cpe(fat)), and in a model of high-fat diet-induced obesity in C57BL/6J mice.
A recent report showed that chronic treatment with sildenafil improve glucose metabolism in a model of high-fat fed mice, without directly affecting Akt-1 phosphorylation [21].
The mice model of high-fat diet-induced fatty liver was considered a good model for the study of metabolic syndrome [ 16, 17].
In a mouse model of high-fat diet-induced obesity, it was shown that adiposity could lead to exacerbation of inflammatory bowel disease [ 37].
