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The cortical abnormalities found in animal models of fetal alcohol syndrome (FAS) suggest a disruption of axon growth.
We have shown that accurate 3D models of fetal and infant anatomy, including internal organs, can be created by rapid prototyping of whole-body post-mortem MR images.
In summary, post-mortem MR imaging and rapid prototyping can create accurate 3D models of fetal and infant anatomical features and these models may have many potentially important medical and medicolegal applications, whilst removing the need for retention of organs.
Animal models of fetal ethanol exposure play an important role in furthering this research.
Common animal models of fetal malnutrition include placental insufficiency, food restriction, protein restriction, micronutrient deficiency, and glucocorticoid exposure.
As in many other areas of biomedical research, animals have nevertheless proven valuable experimental models of fetal programming due to their genetic homogeneity, more controlled environment, accessibility to obtain fetuses at different developmental stages, and feasibility for interventions during gestation.
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Background/Purpose: The authors have described previously the use of engineered fetal cartilage in a large animal model of fetal tracheal repair.
Previously, the novel peptides NAPVSIPQ and SALLRSIPA were shown to prevent alcohol-induced fetal death and growth abnormalities in a mouse model of fetal alcohol syndrome.
We studied their usefulness, based on amniotic fluid concentrations, in an ovine model of fetal aortic stenosis and in response to fetal cardiac intervention.
To determine whether oxidative stress plays a role in the development of hypertension using a mouse model of fetal programming induced by endothelial nitric oxide synthase deficiency.
The objective of this work was to evaluate whether activity-dependent neurotrophic factor-12 could prevent alcohol-induced damage in a model of fetal alcohol syndrome.
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