Empirically, this cognitive architecture accounts qualitatively for the data described by Baars' Global Workspace Theory (GWT), and Franklin's LIDA architecture, including state-of-the-art models of conscious contents in action-planning, Baddeley-style Working Memory, and working models of episodic and semantic longterm memory.
The interpretation of the results obtained is not straightforward, with particular reference to those from the models of episodic selection.
The lack of impairment in regularity is in contrast to reports on mouse models of episodic ataxia type 2 (EA-2), in which PC firing becomes more variable and normalization of this variability reduces ataxic behavioral symptoms (24).
Since deficits in episodic memory are found in a number of neuropsychiatric diseases, such as Alzheimer's disease, for which several pharmacological, lesion and genetic animal models are available, there is a need for animal models of episodic-like memory, which can be used to devise appropriate treatments.
In order to study this type of memory in animals a number of rodent models of episodic-like memory have been developed that make use of rodents' natural propensity to explore novel aspects of their environment (Eacott and Norman, 2004; Kart-Teke et al., 2006; Eacott and Easton, 2007; Good et al., 2007).
(1′S,3′R,4′S -N- 6-phenylpyrimidin-4-yl -4H-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octan]-2-amine,4′S -N- 6-phenylpyrimidin-4-yl -4H-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octan]-2-aminein the mouse novel object recognition (NOR) model of episodic memory.
Based on an earlier neural network model of the hippocampus in which episodic memories were retrieved on every time step [15], an abstract model of episodic memory has been proposed and simulated in [4].
These findings confirm a synergistic interaction in a macaque monkey model of episodic memory between connections carried by the fornix and cholinergic input to the inferotemporal cortex.
This integrated "what-where-which occasion" memory has been suggested to be model of episodic memory in rodents (Eacott and Easton, 2010; Easton et al., 2012).
Clustering has been described by a model of episodic evolution, in which antigenic clusters correspond to periods of neutral evolution and positive selection is restricted to cluster transitions (Koelle et al. 2006; Wolf et al. 2006; Koelle et al. 2010).
We have shown that disconnection of a small region of the ventrolateral prefrontal cortex from the inferotemporal cortex, via placement of a neurotoxic lesion in the ventrolateral prefrontal cortex contralateral to ablation of the inferotemporal cortex, produces a substantial impairment in object-in-place scene memory, a macaque model of episodic memory.
