Sentence examples for models of emphysema from inspiring English sources

Many animal models of emphysema exist, but most of them are insufficiently characterized with respect to the underlying nature (e.g. destructive or developmental) and the degree of the structural alterations.

Invasive pulmonary function measurements are not routinely assessed in mouse models of emphysema and when used they only refer to one time point measurement.

It is possible that this mechanism can help elucidate the skeletal muscle dysfunction in animal models of emphysema and also in human COPD patients, thus contributing to the establishment of therapeutic countermeasures against emphysema-induced muscle damage and cachexia.

It will now be of utmost interest and importance to see whether further animal experiments will confirm that GHK is indeed able to revert disease in vivo, using relevant animal models of emphysema or COPD.

Indeed, we have previously shown that semi-quasistatic measurements of compliance with Scireq-Flexivent, as used by others, are less reliable than compliance (Cchord) measurements obtained with the Buxco as in the present study, and that measures of compliance and TLC are probably the best markers for mouse models of emphysema (Vanoirbeek et al., 2010).

First, no experimental model of emphysema is able to perfectly reproduce all features of human emphysema.

In a murine model of emphysema, the mice that overexpress the sod3 gene or are treated with a SOD mimetic have improved lung compliance, decreased neutrophil influx, release of proinflammatory mediators, and oxidative damage [22].

However, the rat model of emphysema induced by multiple elastase instillations, as used in the present study, was associated with cardiorespiratory functional changes and diaphragmatic injury and may thus provide an efficient tool to better understand the role of PCV and PSV, with potential for translation into clinical practice.

Our model of emphysema, caused by smoke exposure and identified with pathologic criteria, reflects partly the pathobiologic features of emphysematous COPD which is induced commonly by inhalation of noxious gasses and particulate matter resulting in a chronic persistent inflammation in the lung [34].

In a mouse model of emphysema, it was shown that adiponectin may protect against the emphysema development.

To our knowledge, no long-term functional measurements have been performed in the elastase-induced mouse model of emphysema.