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Development of glaucoma also coincided with increased levels of TNFα and TNFα-inducible genes in laser induced rodent models of elevated IOP [7][8].
This is consistent with evidence that models of elevated Wnt signaling, such as SFRP-1 knockout mice or G171V-LRP5 transgenic mice, do not exhibit increased bone resorption [66], [67].
This is in contrast to in vivo models of elevated myocardial load, which are, to some extent, obscured by an indispensable accompanying neuroendocrine activation.
Krauss et al. demonstrated that LBN lowered IOP with greater efficacy than equimolar concentrations of latanoprost in multiple animal models of elevated IOP [ 33].
A direct link between mTOR signaling and the regulation of protein synthesis and muscle mass has been well documented in models of elevated mechanical loading.
2D:4D has also been shown to be sexually dimorphic in endocrine models of elevated (congenital adrenal hyperplasia) and reduced fetal testosterone exposure (complete androgen insensitivity syndrome).
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The application of a pneumoperitoneum served as a model for elevated IAP.
Romanticism has been seen as "the revival of the life and thought of the Middle Ages", reaching beyond Rationalist and Classicist models to elevate medievalism and elements of art and narrative perceived to be authentically medieval, in an attempt to escape the confines of population growth, urban sprawl and industrialism, embracing the exotic, unfamiliar and distant.
Using the first transgenic animal model to elevate circulating levels of IGF-I to those comparable to women at increased risk of breast cancer, we showed that moderately high levels of systemic IGF-I have no effect on pubertal mammary gland development, initiating mammary tumorigenesis or promoting ErbB2 driven mammary carcinogenesis.
The amplitude of the pulse-synchronous IMP oscillations increases with increasing absolute level of IMP during a model of abnormally elevated IMP in the human leg.
Mean intramuscular pressure (IMP) and standard deviation during a model of abnormally elevated IMP that was induced by venous obstruction of a casted leg.
Related(20)
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