Sentence examples for models of disuse from inspiring English sources

Trabecular bone, however, is more detrimentally affected than cortical bone in other animal models of disuse.

In a second paper these genes were compared with two animal models of disuse induced muscle wasting, leading to 53 commonly changed genes.

When comparing the septic patient responses in gene expression, with animal models of disuse, in general a much poorer agreement is observed.

It has been attributed to the activation of various protein degradation pathways in several models of disuse, such as denervation, unloading, cachexia, or aging [ 11, 12].

Indeed, both decreased rates of protein synthesis and increased rates of protein degradation have been observed in several animal models of disuse atrophy (Bodine, 2013).

Because blocking myostatin in an adult wild-type mouse induces profound muscle hypertrophy, we applied a soluble ActRIIB receptor to models of disuse (limb immobilization) and denervation (sciatic nerve resection) atrophy.

This study was designed to evaluate its effects on biochemical biomarkers of bone metabolism and on bone density and structure in an experimental model of disuse osteoporosis induced by cast application in horses.

Using a rat model of disuse osteoporosis, Barou, et al. [23] found poor correlation for TbTh by μCT versus bone histomorphometry and suggested that 3D- μCT may be more sensitive than histomorphometry in detecting changes in BMD and trabeculae.

It is well known that hindlimb suspension (HS), a widely used model of disuse and hypogravity, leads to progressive atrophy of postural skeletal muscle [ 1, 5, 6].

Although sciatic neurectomy is a widely used model of disuse [61], it is known to induce some degree of physiological stress, although probably less than tail suspension, as well as reduced innervation of the neurectomized limb [62].

Increased expression of these ligases in mouse models of muscle disuse results in degradation of structural components of the muscle fibers such as the myofibrillar proteins (myosin, titin, troponin, nebulin, myotilin; [7] [8]. Conversely, induced muscle atrophy is prevented in MuRF1 and MAFbx Knockout (KO) mice [6], [7].