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Endochondral ossification from the central fibrous tissue has been shown in the distraction gap in experimental models of distraction osteogenesis in rabbits [24, 26].
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We hypothesised that therapeutic angiogenesis could enhance bone formation and challenged the hypothesis in an experimental model of distraction osteogenesis.
The results are conceptualised in a succinct model of distraction linking multiple factors with mechanisms that induced the attentional shift.
A reliable experimental rabbit model of distraction spinal cord injury (SCI) was established to successfully simulate gradable and replicable distraction SCI.
We have observed that cytotoxic chemotherapy has a detrimental affect on bone formed in a lapine model of distraction osteogenesis.
We explored the hypothesis that there is a relationship between DXA assessment of regenerate bone and structural mechanical properties in an animal model of distraction osteogenesis.
On the other hand, Fink et al. [44] denied the "tension-stress effect", showing numerous cartilage islands within all specimens in a canine model of distraction osteogenesis.
Kolbeck et al. [9] reported a high correlation between digital radiographic densimetric evaluation of regenerate and torsional force measurements in a micropig animal model of distraction.
We therefore used a rabbit model of distraction osteogenesis to determine that cytotoxic agents had a detrimental effect on regenerate bone formed by this technique.
And no clinical or radiographic comparative study has been reported, especially in the model of distraction osteogenesis.
Recently, a rat model of mandibular distraction was described that provides an excellent environment for deciphering the molecular mechanisms that mediate distraction osteogenesis.
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