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While the work is in its infancy, there is significant optimism that next steps will lead to organ culture models of disc degeneration and regeneration, and ultimately to in vivo rescue of degenerating discs with stem cell treatment.
Animal models of disc degeneration are limited, with no ideal model [ 3].
Unfortunately, because of differences in anatomy, there are no ideal animal models of disc degeneration.
Establishing clinically relevant models of disc degeneration has also proven difficult.
Models of disc degeneration have severe limitations [ 3] with none providing the ideal test environment.
In certain animal models of disc degeneration, treatments have successfully diminished or even reversed degeneration-like characteristics (Masuda, 2008).
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In an attempt to solve this dilemma, we transplanted autologous mesenchymal stem cells (MSCs) from bone marrow into a rabbit model of disc degeneration to determine if stem cells could repair degenerated IVDs.
The optimal neural model of disc brake operation has been shown to be valid for predicting the brake factor C variation of the cold disc brake over a wide range of brake's operating regimes and for different types of friction material.
A rabbit anular puncture model of disc degeneration was established, as previously reported [ 23].
Furthermore, as our understanding of disc degeneration advances, a reproducible animal model of disc degeneration will enable controlled testing of therapeutic strategies.
A limitation of this study is that the well-characterized rabbit anular puncture model [ 23] used is a short-term (1-month) injury animal model of disc degeneration.
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