Our previous studies have demonstrated that XCHT improved depressive-like behavior in several animal models of depression.
In animal models of depression, administration of leptin has been shown to improve depressive behaviors and exert antidepressant-like effects [ 10, 11].
Restoration of body weight by antidepressant treatment, particularly citalopram, in animal models of depression has been shown to to accompany recovery from a depressive-like state [ 130].
The central nervous system (CNS) depressant activity of C. diffusa was evaluated by the classical models of depression as open field, hole cross, forced swimming, tail suspension, and thiopental sodium induced sleeping time tests in mice.
In conclusion, these various findings reiterated the antidepressant-like effects of'6n' in behavioral models of depression.
Overall, results support cognitive models of depression and suggest that implicit cognition reliably predicts past, current, and future depression.
Studies with experimental models of depression, where stressful procedures are used, should include a control group of untreated intact animals.
Thus, the present study was designed to investigate thoroughly the antidepressant potential of etazolate using rodent behavioral models of depression.
Xanthone, a component of Hypericum perforatum L., has been shown to be effective in animal models of depression.
Vulnerability models of depression posit that individual differences in trait-like vulnerabilities emerge early in life and increase risk for the later development of depression.
Most of present models of depression are also devalued due to the fact that they typically address only one of the aforementioned pathogenetic factors.
