With the assistance of biomaterials, improvement in treatment efficiency has been demonstrated in numerous animal models of degenerative diseases compared with routine free cell-based therapy.
Given that this is the first report of a protective effect of SurR9-C84A following an oxidative stress injury, further work should be done to study the effects of SurR9-C84A on in vivo models of degenerative diseases.
JSM and MTS have a financial interest in Luminomics, Inc., a small biotechnology company that uses the nitroreductase transgene-based system of targeted cellular ablation as a platform for studying cell-specific regeneration using models of degenerative and autoimmune diseases.
Green tea (Camellia sinensis), a popular beverage worldwide, has been shown to exert antimutagenic, antiproliferative, and anticarcinogenic effects, as well as anti-inflammatory activity in models of degenerative disorders [ 27- 29].
As OPP displayed significant antioxidant activities and conferred positive outcomes in various animal models of degenerative diseases without causing toxicity [ 21- 23], we hypothesised that it might also have significant biological effects in animals during healthy states.
Although studies using transgenic mice [ 50- 52] suggest that in these murine models of degenerative joint disease, ADAMTS5 is the pathologically induced aggrecanase, our data suggest that ADAMTS4 is the aggrecanase induced by proinflammatory cytokines in the human OA synovium.
