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This lack of effect stands in contrast to reported effects of sodium channel antagonists on preclinical models of cutaneous hyperalgesia or effects of lamotrigine on clinical neuropathic pain.
The general gene expression profile of target tissues of GVHD has been previously analyzed only in mouse models of cutaneous and hepatic GVHD [70], [71].
Animal models of cutaneous inflammatory pain were developed initially as pharmacodynamic assays of anti-inflammatory drug activity, particularly for NSAIDs.
Animal studies have demonstrated that activation of cannabinoid receptors attenuates inflammation and nociceptive processing in models of cutaneous and joint inflammation [ 10- 14].
Further work is required to evaluate the impact of these drugs in other mammalian models of cutaneous inflammation and in alleviating skin inflammation in humans.
In relation to our interest in developing preclinical models of cutaneous carcinogenesis under immunosuppressed conditions, during the last two weeks of the experiment, the mice were also receiving the immunosuppressive agent azathioprine (10 mg/kg) in the drinking water.
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Dewan, M. Z. et al. Synergy of topical toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer.
In view of the promising activity of Ru-clotrimazole complexes against Leishmania major (L. major), the present work sought to investigate the anti-leishmanial activity of the AM162 complex in the murine model of cutaneous leishmaniasis.
This study presents a method to determine relative quantitation of nanoparticle (NP) abundance in histological samples in an ex vivo model of cutaneous exposure to metal oxide NPs using enhanced darkfield microscopy (EDFM) with hyperspectral imaging (HSI) and mapping.
During her research year, Angelina Seffens will work on a collaborative project with Larisa Geskin, MD, in Columbia's Department of Dermatology, and Sergei Koralov, PhD, at NYU to create a mouse model of cutaneous t-cell lymphoma (CTCL), a T-cell malignancy that homes to the skin.
The contributions of L-selectin, P-selectin, and ICAM-1 to interactions between lymphocytes and endothelium was examined using allogeneic skin graft rejection as a model of cutaneous inflammation.
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