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The flow fields inside three polydimethylsiloxane (PDMS) models of coronary artery bypass grafts, including the coupled SQA graft design, a conventional ETS anastomosis, and a parallel side-to-side (STS) anastomosis, are investigated under pulsatile flow conditions using particle image velocimetry (PIV).
Its vascular effects were evaluated in two models of coronary vascular reactivity in primates: 1) the paradoxical vasoconstriction to acethylcholine (Ach) coronary infusion after 5 months of mildly atherogenic diet in ovariectomized (OVX) Cynomolgus monkeys and 2) the pharmacologically evoked coronary vasospasm in the OVX Rhesus monkey.
Our findings suggest avenues for further research and indicate that factors involved in regulating apoptosis should be included in future models of coronary artery development.
Interestingly, PCr treatment reduced necrotic tissue injury and improved contractile function in animal models of coronary artery ligation [102] and ischemia reperfusion injury [103].
Studies using I-MIBG in animal models of coronary artery occlusion have revealed more extended nerve damage than myocardial injury in MI [ 95].
For example non-transgenic models of coronary artery disease involve acute ischemia rather than progressive atherosclerotic coronary disease which would trigger cardiac remodeling [ 1].
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Strony, J., Beaudoin, A., Brands, D. & Adelman, B. Analysis of shear stress and hemodynamic factors in a model of coronary artery stenosis and thrombosis.
An open-chest model of coronary occlusion and acute ischemia was used in 14 adult pigs.
We previously demonstrated that adenoviral-mediated CRNK gene transfer improved survival and LV function, and slowed LV remodeling in a rat model of coronary artery ligation-induced HF.
In this model of coronary occlusion during angioplasty balloon inflation, the automated patency assessment program appears to detect coronary angioplasty balloon occlusion and reperfusion within seconds in all occlusions causing a peak ST elevation of 200 microV or greater.
We previously demonstrated that acute administration of beta AR blocker during cardiopulmonary bypass (CPB) in an animal model of coronary artery bypass grafting (CABG) surgery attenuates beta AR desensitization, whereas chronic oral beta-blockade therapy in patients undergoing CABG surgery does not prevent it.
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