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The antagonists were tested in two models of contact skin reaction.
These data are consistent with our findings, although we used two different models of contact skin reaction.
Histology and immunohistochemistry confirmed compound efficacy at 0.5 and 1 mg/kg in modulation of innate and adaptive immunity in mouse models of contact skin reaction.
In our study the antagonistic property of [44AANA47]-CCL5 was extended into an anti-inflammatory effect in two murine models of contact skin reaction.
Down-regulation of IL-12p70, IL-6, MCP-1 and IFN-g by Met-CCL5 in both models of contact skin reaction suggest efficacy of the compound in modulation of both innate and adaptive responses.
In this study we tested two CCL5 antagonists in two models of contact skin reaction, ICD and CHS, to demonstrate that blocking the receptor or the ligand are both effective strategies to inhibit skin inflammation.
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Using mechanics models of contacting surfaces under both normal and tangential loads, a mechanistic framework has been developed for assessing material resistance to initiation of abrasive damage.
The main topics of the Persson's model of contact mechanics are reviewed in this section.
Here, Persson's model of contact mechanics is extended to such cases.
Open image in new window Figure 6 Approximate model of contact pressure.
2, Persson's model of contact area and interfacial surface separation is reviewed.
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