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Taketo, M.M. & Edelmann, W. Mouse models of colon cancer.
Su, F. et al. HDL mimetics inhibit tumor development in both induced and spontaneous mouse models of colon cancer.
This study uses preclinical mouse models of colon cancer to show that STAT3 loss results in mitochondrial damage and enhanced mitophagy.
Early studies using animal models of colon cancer indicated that NSAIDs were chemopreventive (Kudo et al., 1980; Pollard and Luckert, 1981).
Peptides mimicking the proteins associated with HDL were also shown to inhibit tumor development in both induced and spontaneous mouse models of colon cancer6.
Necela, B. M., Carr, J. M., Asmann, Y. W. & Thompson, E. A. Differential expression of microRNAs in tumors from chronically inflamed or genetic (APC(Min/+)) models of colon cancer.
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"And it didn't help Nancy's nerves that the press was using models of colons to show the public exactly what was happening to Ronnie's guts--was there to be no privacy, even about one's colon?" Leighton scrambles people and places with the joyous abandon of a Mad Hatter hostess who's lost her seating chart.
19 CPA also reduced the occurrence of colonic polyps in a rat model of colon carcinogenesis.
We have recently shown that ERK5 inhibition enhances the anticancer properties of 5-FU in a murine xenograft model of colon cancer36.
Among her more recent research, Dr. Chen developed a 3D model of colon cancer, grown from human stem cells, that she and her colleague Dr. Todd Evans used to screen drugs that could effectively treat the disease.
Additional evidence of a Th-1 response is demonstrated by tumor growth inhibition in a mouse model of colon cancer metastasis.
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