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Modern models of chromosome organization do not predict the existence of a peripheral chromosome scaffold domain, and thus our observations have conceptual implications for understanding chromosome architecture.
Yet, while it is now generally agreed that chromosomes in the cell nucleus are organized as chromosome territories, present models of chromosome territory architecture differ widely with respect to the possible functional implications of dynamic changes of this architecture during the cell cycle and terminal cell differentiation.
Integration of empirical data with proposed models of chromosome evolution was performed to understand the probable conditions for Tonatia's karyotypic evolution.
In general, models of chromosome speciation have the same point of view: the reduction of gene flow through the accumulation of chromosomal differences between the progenitor and their descendants that leads to impaired fertility or viability of interspecific hybrids [ 14].
To test for departures from models of chromosome pairing (Table 1), we constructed a 95% confidence interval based on the binomial distribution for each observed proportion of heterozygous individuals using the pooled marker data from each progeny class separately (S2G, S2N, BC1N).
This review highlights how recent studies over the last 5 years employing chromosome conformation capture combined with classical models of chromosome organization based on decades of microscopic observations, are providing new insights into the three-dimensional organization of chromatin inside the interphase nucleus and within mitotic chromosomes.
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Models of chromosomes and DNA were also put on show.
In order to investigate the frequency of nondisjunction in MM, we then compared the segregation patterns found in multipolar ana-telophase cells (Table 1; Figure 4) to three models of chromosomes segregation.
The relatively small number of genomes from anciently distinct metazoan lineages and the fragmented nature of draft genome assemblies still limit both the search for ancient whole genome duplications and the power of the data to constrain models of chromosome-scale genome structure evolution.
Also, considering the specified genetic model of chromosome X, the permutation performance of autosome and chromosome X were specified (Table 1).
Consequently, and assuming the scaffold/radial loop model of chromosome structure, mouse metaphase I chromosomes show an organization similar to that found in mitotic metaphase chromosomes ([4], [57]) (Fig. 6).
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