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There are few reproducible models of blast injury, so it is difficult to evaluate new or existing therapies.
Conventional models of blast injuries require the use of real explosives and complex shock tubes or blast generators to create shock waves.
Current experimental models of blast injuries used to study blast-induced neurotrauma (BINT) vary widely, which makes the comparison of the experimental results extremely challenging.
These knowledge gaps can be addressed by translational research that utilizes animal models of blast neurotrauma.
23 The finding of reduced NAA/Cr is consistent with the findings of oxidative injury in rat models of blast.
Clinical relevance and translational utility demand that animal models of blast neurotrauma emphasize experimental fidelity of the resulting brain injury in the context of the inciting traumatic insult.
Similar(49)
This review will address key issues for animal models of blast-related TBI and CTE.
Many animal models of blast-induced injury exist, although the precise biomechanics of blast-related traumatic injury and its neuropathological consequences are the subject of debate [ 43, 44].
LS-DYNA provides the LOAD_BLAST or LOAD_BLAST_ENHANCED for modeling of blast loads.
In the authors' opinion, the deviations between the simulated and tested results of CTEST20 column mainly generate from simplified modeling of blast load.
This might be due to the erosion of concrete material at the two ends and the simplified modeling of blast load by adopting LOAD_BLAST_ENHANCED in LS-DYNA (Hallquist 2007).
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