Sentence examples for models of atrophy from inspiring English sources

Both MAFbx and MuRF1 have been shown to be up-regulated in different models of atrophy, conferring them the status of muscle atrophy markers [8], [9].

We therefore examined the activation of both the mTORC1 and mTORC2 complexes in our models of atrophy and ActRIIB treatment.

Both models of atrophy demonstrated an increase in active pERK1/2 compared with their respective controls (Fig. 2B).

In both models of atrophy, we found that p21 expression is unchanged, both with and without ActRIIB treatment.

Future studies will examine the trophic effect of calpain 1 inhibitors in models of atrophy and calpain 1 activators in models of hypertrophy.

Because Akt and SGK can regulate the pro-growth mTOR pathway, we also examined whether this pathway was dysregulated in our models of atrophy.

Critically, this pattern of gene expression differs markedly from muscle unloading in humans [24] and from animal models of atrophy-sepsis, indicating that our findings are not driven by inactivity nor are they adequately represented by preclinical models.

Previous studies in different models of atrophying muscles reported that apoptosis is not confined to myofibres, as apoptosis occurs in stromal cells in response to underweighting (Allen et al., 1997), hypertension (Gobé et al., 1997), heart failure (Vescovo et al., 1998) and in dystrophic muscles (Sandri et al., 1998).

Short-term SRT2104 treatment preserves bone and muscle mass in an experimental model of atrophy.

The success of these attempts appears to depend on the action of growth factors used, the delivery system employed, and the model of atrophy studied.

Using a second model of atrophy, where endocrine signals rather than inactivity promote muscle loss, both the soleus and tibialis muscles from SRT2104-treated mice were found to be more resistant to fasting-induced atrophy (Fig. S4A).